Title: Mtor Inhibitor Rad001 Promotes Metastasis in a Rat Model of Pancreatic Neuroendocrine
نویسندگان
چکیده
1 cancer 2 3 Authors and Affiliations: Stefan E. Pool, S. Bison, Stuart J. Koelewijn, Linda M. van der Graaf, 4 Marleen Melis, Eric P. Krenning, Marion de Jong 5 6 Department of Nuclear Medicine and Radiology, Erasmus MC, Rotterdam, the Netherlands 7 8 None of the authors has a conflict of interest to declare. 9 10 Running title: Augmentation of metastatic tumor behavior by mTOR inhibition. 11 12
منابع مشابه
mTOR inhibitor RAD001 promotes metastasis in a rat model of pancreatic neuroendocrine cancer.
Inhibition of mTOR is commonly considered a valid target in cancer treatment, but this assertion does not address effects on the immune microenvironment that may be detrimental to cancer treatment. Here we show how administration of the mTOR inhibitor RAD001 (everolimus) results in the occurrence of distant metastasis in a rat model of pancreatic cancer. RAD001 was administered twice weekly for...
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BACKGROUND/AIM Tumors exhibiting constitutively activated PI(3)K/Akt/mTOR signaling are hypersensitive to mTOR inhibitors such as RAD001 (everolimus) which is presently being investigated in clinical phase II trials in various tumor entities, including neuroendocrine tumors (NETs). However, no preclinical data about the effects of RAD001 on NET cells have been published. In this study, we aimed...
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Background/Aim: Tumors exhibiting constitutively activated PI(3)K/Akt/mTOR signaling are hypersensitive to mTOR inhibitors such as RAD001 (everolimus) which is presently being investigated in clinical phase II trials in various tumor entities, including neuroendocrine tumors (NETs). However, no preclinical data about the effects of RAD001 on NET cells have been published. In this study, we aime...
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Pancreatic neuroendocrine tumors (PanNETs) are frequently diagnosed at unresectable stage and remain a medical challenge. Everolimus (RAD001, Afinitor(®), Novartis, Basel, Switzerland), an orally administered inhibitor of mammalian target of rapamycin (mTOR), was recently approved by the Food and Drug Administration to treat patients with advanced PanNETs. This review will examine the mechanism...
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